A design-based view of signaling and memory circuits in mammalian cells
ABSTRACT: Cells use circuits of interacting genes and proteins to control their behaviors, but the design principles that govern genetic circuit architecture usually remain mysterious. Our lab seeks to identify and understand such design principles by constructing or re-wiring minimal versions of key pathways in living cells, and studying their behavior quantitatively and dynamically at the single-cell level. In this talk, I will discuss new work on mammalian signaling pathways and epigenetic memory systems. This work reveals unexpected principles underlying these systems and shows how higher-level representations can provide simple and predictive views of complex molecular pathways.