Figure 1 (A and B) Simulated data for two regions with different LD patterns that contain 35 SNPs. A and B are obtained by considering the 100 kbp upstream and downstream of rs10962894 and rs4740698, respectively, from the Wellcome Trust Case–Control Consortium study for coronary artery disease (CAD). (C and D) The rank of the causal SNP in additional simulations for the regions in A and B, respectively. We obtain these histograms from simulation data by randomly generating GWAS statistics using multivariate normal distribution. We apply the simulation 1000 times.