Publications

Our group publishes papers presenting new methodologies, describing the results of studies that use our software, and reviewing current topics in the field of Bioinformatics. Scroll down or click here for a complete list of papers produced by our lab. Since 2013, we write blog posts summarizing new research papers and review articles:

GWAS

Mouse Genetics

Population Structure

Review Articles

Publications

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2018

Sul, Jae Hoon; Martin, Lana S; Eskin, Eleazar

Population structure in genetic studies: Confounding factors and mixed models. Journal Article

PLoS Genet, 14 (12), pp. e1007309, 2018, ISSN: 1553-7404.

Abstract | Links | BibTeX | Tags: Mixed Models, Population Structure Methods

2016

Sul, Jae Hoon; Bilow, Michael; Yang, Wen-Yun Y; Kostem, Emrah; Furlotte, Nick; He, Dan; Eskin, Eleazar

Accounting for Population Structure in Gene-by-Environment Interactions in Genome-Wide Association Studies Using Mixed Models. Journal Article

PLoS Genet, 12 (3), pp. e1005849, 2016, ISSN: 1553-7404.

Abstract | Links | BibTeX | Tags: gene-by-environment interactions, genome-wide association studies, Mixed Models

Joo, Jong Wha J; Hormozdiari, Farhad; Han, Buhm; Eskin, Eleazar

Multiple testing correction in linear mixed models. Journal Article

Genome Biol, 17 (1), pp. 62, 2016, ISSN: 1474-760X.

Abstract | Links | BibTeX | Tags: genome-wide association studies, Mixed Models, Multiple Testing

Joo, Jong Wha J; Kang, Eun Yong; Org, Elin; Furlotte, Nick; Parks, Brian; Hormozdiari, Farhad; Lusis, Aldons J; Eskin, Eleazar

Efficient and Accurate Multiple-Phenotype Regression Method for High Dimensional Data Considering Population Structure. Journal Article

Genetics, 204 (4), pp. 1379-1390, 2016, ISSN: 1943-2631.

Abstract | Links | BibTeX | Tags: Mixed Models, Multiple Phenotypes

Schweiger, Regev; Kaufman, Shachar; Laaksonen, Reijo; Kleber, Marcus E; März, Winfried; Eskin, Eleazar; Rosset, Saharon; Halperin, Eran

Fast and Accurate Construction of Confidence Intervals for Heritability. Journal Article

Am J Hum Genet, 98 (6), pp. 1181-92, 2016, ISSN: 1537-6605.

Abstract | Links | BibTeX | Tags: Mixed Models

2015

Furlotte, Nicholas A; Eskin, Eleazar

Efficient Multiple Trait Association and Estimation of Genetic Correlation Using the Matrix-Variate Linear Mixed-Model. Journal Article

Genetics, 200 (1), pp. 59-68, 2015, ISSN: 1943-2631.

Abstract | Links | BibTeX | Tags: Heritability, Mixed Models, Multiple Phenotypes

2013

Kostem, Emrah; Eskin, Eleazar

Improving the accuracy and efficiency of partitioning heritability into the contributions of genomic regions. Journal Article

Am J Hum Genet, 92 (4), pp. 558-64, 2013, ISSN: 1537-6605.

Abstract | Links | BibTeX | Tags: Heritability, Mixed Models

Sul, Jae Hoon; Eskin, Eleazar

Mixed models can correct for population structure for genomic regions under selection. Journal Article

Nat Rev Genet, 2013, ISSN: 1471-0064.

Links | BibTeX | Tags: Mixed Models, Population Structure Methods

Sul, Jae Hoon; Han, Buhm ; Ye, Chun ; Choi, Ted ; Eskin, Eleazar

Effectively Identifying eQTLs from Multiple Tissues by Combining Mixed Model and Meta-analytic Approaches Journal Article

PLoS Genet, 9 (6), pp. e1003491, 2013, ISSN: 1553-7404.

Abstract | Links | BibTeX | Tags: Expression QTLs, Meta-Analysis, Mixed Models, Multiple Phenotypes

2012

Listgarten, Jennifer; Lippert, Christoph ; Kadie, Carl M; Davidson, Robert I; Eskin, Eleazar ; Heckerman, David

Improved linear mixed models for genome-wide association studies. Journal Article

Nat Methods, 9 (6), pp. 525-6, 2012, ISSN: 1548-7105.

Links | BibTeX | Tags: Mixed Models, Population Structure Methods

2010

Kenny, Eimear E; Kim, Minseung ; Gusev, Alexander ; Lowe, Jennifer K; Salit, Jacqueline ; Smith, Gustav J; Kovvali, Sirisha ; Kang, Hyun Min ; Newton-Cheh, Christopher ; Daly, Mark J; Stoffel, Markus ; Altshuler, David M; Friedman, Jeffrey M; Eskin, Eleazar ; Breslow, Jan L; Pe'er, Itsik

Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population. Journal Article

Hum Mol Genet, 20 (4), pp. 827-39, 2010, ISSN: 1460-2083.

Abstract | Links | BibTeX | Tags: Mixed Models

Kang, Hyun Min; Sul, Jae Hoon ; Service, Susan K; Zaitlen, Noah A; Kong, Sit-Yee Y; Freimer, Nelson B; Sabatti, Chiara ; Eskin, Eleazar

Variance component model to account for sample structure in genome-wide association studies. Journal Article

Nat Genet, 42 (4), pp. 348-54, 2010, ISSN: 1546-1718.

Abstract | Links | BibTeX | Tags: Mixed Models, Population Structure Methods

2008

Kang, Hyun Min; Ye, Chun ; Eskin, Eleazar

Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Journal Article

Genetics, 180 (4), pp. 1909-25, 2008, ISSN: 0016-6731.

Abstract | Links | BibTeX | Tags: Expression QTLs, Mixed Models