Review Article: GWAS and Missing Heritability

cacm-coverA couple of years ago I was asked to write a review article on the progress of my field (computational genetics) targeted toward computer scientists. My article “Discovering Genes Involved in Disease and the Mystery of Missing Heritability” was just published on the cover of the Communications of the ACM. This article is written to be an introduction to the field as well as describe the rapid progress over the past decade in terms of the discovery of large number of variants involved in common human diseases. The article is written assuming no background in biology and is designed to be accessible to researchers and students outside the field. I hope that it will encourage other computational researchers to get involved in genetics.  The journal also made a video highlighting this article which is available here:

Discovering Genes Involved in Disease and the Mystery of Missing Heritability from CACM on Vimeo.

The full citation to the article is:
 

Eskin, Eleazar

Discovering Genes Involved in Disease and the Mystery of Missing Heritability Journal Article

In: Commun. ACM, 58 (10), pp. 80-87, 2015, ISSN: 0001-0782.

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